Dr. Uma Shanker

Contact Info
Dr. Uma Shanker
+91-7508463750
Department of Pharmacology, Lab No 402, North Block, Ghudda Bathinda
Dr. Uma Shanker

Assistant Professor Department of Pharmacology School of Pharmaceutical Sciences

Qualification

B.Pharm, M.S. (Pharm), Ph.D

Ph.D. from National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, Punjab, India

M.S Pharm (Pharmacology & Toxicology) from National Institute of Pharmaceutical Education and Research, S.A.S. Nagar, Mohali, Punjab, India

B. Pharmacy from University Institute of Pharmaceutical Sciences (UIPS), Panjab University, Chandigarh, India

Experience
Teaching Experience 

Assistant Professor, Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda (Since January 2020).

Assistant Professor (Guest Faculty), Department of Pharmacology, Central University of Punjab, Ghudda, Bathinda (August 2019- January 2020).

Research Experience 

Senior Research Fellow at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India (JUNE 2016-JUNE 2019)

Junior Research Fellow at National Institute of Pharmaceutical Education and Research (NIPER), Mohali, Punjab, India (JUNE 2014-JUNE 2016)

Administrative Experience

Department Placement Coordinator (Since January 13, 2020)

Member of Institute Animal Ethics Committee (IAEC), at CUPB, (Since March 16, 2021)

Member, Academic and Administrative Committee, Department of Pharmacology

Member, Curriculum Design and Development Committee, Department of Pharmacology

Any Other Experience

Around 8 years of research experience in pharmacological research, drug discovery, and development, particularly in diabetes, non-alcoholic steatohepatitis & its complications (nephropathy & cardiomyopathy), fibrosis, epigenetics, aging, nutrition, and preclinical toxicity testing.

Research Area

Diabetes Mellitus

Non-alcoholic fatty liver disease (NAFLD)

Non-alcoholic steatohepatitis (NASH)

Epigenetics

Metabolic disorders associated with secondary complications such as nephropathy & cardiomyopathy

Preclinical toxicity studies

Research Interests
  • In vitro and in vivo Pharmacology
  • Pharmacological screening of phytochemicals, semisynthetic, and synthetic drugs in animal models of several diseases such as type 1 and type 2 diabetes mellitus, NAFLD, NASH, and associated secondary complications such as nephropathy & cardiomyopathy
  • To decipher the novel mechanisms involved in disease pathology relating to epigenetics. 
  • Molecular Pharmacology
  • To explore the toxicity of NCE and phytochemicals
Research Grants/Projects
  1. Pharmacological evaluation of vincamine in diet induced non-alcoholic steatohepatitis: in vitro and in vivo study. UGC, START-UP GRANT (Rs 10 Lakh) (Year 2021-2023)
  2. To check the role of epigenetic markers in diabetes and its association with one- carbon metabolites in type 2 diabetes patients of Malwa region of Punjab. Research seed money funded by Central University of Punjab. Research Seed Money (RSM) (Rs 3 Lakh)
Professional Affiliation
  1. Member of The Epigenetic society EST 1994
Professional Recognition/Awards/Scholarships
  • Central University’s Research Award -2020-21 given in the year 2022
  • 2019; International Travel Support (ITS)” granted by Indian Council of Medical Research (ICMR), Govt. of India [Letter No. : 3/2/TG-99/HRD-2019 (12)].Miglani Memorial Stipend Award by P.U. Alumni association at Panjab University for the academic session 2011-2012
  • Kamal Bathala Memorial Scholarship Award at alumni function of U.I.P.S., Panjab University 2012
  • Qualified GPAT-2012
  • Qualified NIPER-JEE 
  • Qualified NIPER JEE-PhD
Research Collaboration

Prof.  Ralf Weiskirchen,  Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, University Hospital Aachen (UKA), RWTH University Aachen Pauwelsstr. 30, D-52074 Aachen, Germany

Dr. Amit Khurana, PhD, DAAD-PRIME (Marie-Curie CO-FUND) Fellow, DST-DAAD Fellow, DBT-CNPq Fellow, Institute of Molecular Pathobiochemistry, Experimental Gene Therapy and Clinical Chemistry, University Hospital Aachen (UKA), RWTH University Aachen
Pauwelsstr. 30, D-52074 Aachen, Germany 

Publications

Publications

  1. L-Methionine supplementation attenuates high-fat fructose diet-induced non-alcoholic steatohepatitis by modulating lipid metabolism, fibrosis and inflammation in rats. Umashanker Navik*, Vaibhav G Sheth, Nisha Sharma and  Kulbhushan Tikoo. Food and Function (Accepted March 31, 2022) (IMPACT FACTOR: 6.317) 
  2. Apoptosis and Pharmacological Therapies for Targeting Thereof for Cancer Therapeutics. Vishakha Singh, Amit Khurana, Umashanker Navik, Prince Allawadhi, Kala Kumar Bharani, and RalfWeiskirchen Sci MDPI (Accepted 28 March 2022)
  3. Oxidative stress in the pathophysiology of type 2 diabetes and related complications: Current therapeutics strategies and future perspectives. Jasvinder Singh Bhatti , Abhishek Sehrawat, Jaipriya Mishra, Sidhu IPS, Umashanker Navik, Naina Khullar, Gurjit Kaur Bhatti, P. Hemachandra Reddy. Free Radical Biology and Medicine. (Accepted 22 May  22, 2022)  (IMPACT FACTOR: 8.101)
  4. Gene therapy: Comprehensive overview and therapeutic applications. Nilofer Sayed, Prince Allawadhi, Amit Khurana, Vishakha Singh, Umashanker Navik, Sravan Kumar Pasumarthi, Isha Khurana, Anil Kumar Banothu, Ralf Weiskirchen, Kala Kumar Bharani. Life sciences (2022) DOI: https://doi.org/10.1016/j.lfs.2022.120375. (IMPACT FACTOR: 6.78)
  5. L-Methionine prevents β-cell damage by modulating the expression of Arx, MafA and regulation of FOXO1 in type 1 diabetic rats. Umashanker Navik*, Kajal Rawat, Kulbhushan Tikoo. Acta Histochemica, (2021) DOI: https://doi.org/10.1016/j.acthis.2021.151820. (IMPACT FACTOR: 2.147)
  6. Biomedical applications of polysaccharide nanoparticles for chronic inflammatory disorders: Focus on rheumatoid arthritis, diabetes and organ fibrosis. Prince Allawadhi, Vishakha Singh, Kannan Govindaraj, Isha Khurana, Lopmudra P. Sarode, Umashanker Navik, Anil Kumar Banothu, Ralf Weiskirchen, Kala Kumar Bharani, Amit Khurana. Carbohydrate Polymers, (2021), DOI: https://doi.org/10.1016/j.carbpol.2021.118923 (IMPACT FACTOR: 10.723)
  7. Methionine as a double-edged sword in health and disease: Current perspective and future challenges. Umashanker Navik.,* Sheth, V. G., Khurana, A., Jawalekar, S. S., Allawadhi, P., Gaddam, R. R., Bhatti, J. S., & Tikoo, K. Ageing Research Reviews, (2021).  101500. (Impact factor 11.788)
  8. Decorin as a possible strategy for the amelioration of COVID-19. Prince Allawadhi, Vishakha Singh, Isha , Pushkar Singh Rawat, Akshata Patangrao Renushe, Amit Khurana, Umashanker Navik, Allwadhi S, Kumar Karlapudi S, Banothu AK, Bharani KK. Medical Hypotheses. 2021 Jul;152:110612. DOI: 10.1016/j.mehy.2021.110612. (IMPACT FACTOR: 4.411)
  9. Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management. Pushkar Singh Rawat, Aiswarya Jaiswal,, Amit Khurana, Jasvinder Singh Bhatti, Umashanker Navik* Biomedicine & Pharmacotherapy Volume 139, July 2021, 111708, DOI: 10.1016/j.biopha.2021.111708 (IMPACT FACTOR: 7.419)
  10. Emerging role of non-coding RNA in health and disease. Metabolic brain disease, Gurjit Kaur Bhatti, Naina Khullar, Inderpal Singh Sidhu, Umashanker Navik,  Arubala P. Reddy,  P. Hemachandra Reddy, Jasvinder Singh Bhatti Metabolic brain disease, 1–16. 21 Apr. (2021), DOI:10.1007/s11011-021-00739-y (IMPACT FACTOR: 3.584)
  11. Can bilirubin nanomedicine become a hope for the management of COVID-19? Isha Khurana, PrinceAllawadhi, Amit Khurana, Amit Kumar Srivastava, Umashanker Navik, Anil Kumar Banothu, KalaKumar Bharani, Medical Hypotheses, ISSN: 0306-9877, (2021), 110534, DOI: 10.1016/j.mehy.2021.110534. (IMPACT FACTOR: 4.411)
  12. Is highly expressed ACE 2 in pregnant women “a curse” in times of COVID-19 pandemic? Ankit Dhaundiyal, Puja Kumari, Snehal Sainath Jawalekar, Gaurav Chauhan, Sourav Kalra, Umashanker Navik*, Life Sciences, ISSN: 0024-3205, (2020), 264:118676, DOI: 10.1016/j.lfs.2020.118676. (IMPACT FACTOR:6.78).
  13. Potential of electric stimulation for the management of COVID-19, Prince Allawadhi, Amit Khurana, Sachin Allawadhi, Umashanker Navik, Kamal Joshi, Anil Kumar Banothu, Kala Kumar Bharani, Medical Hypotheses, ISSN: 0306-9877, (2020), 144, 110259, DOI: 10.1016/j.mehy.2020.110259. (IMPACT FACTOR: 4.411).
  14. Unveiling the presence of epigenetic mark by Lactobacillus supplementation in high-fat diet-induced metabolic disorder in Sprague Dawley rats, Nisha Sharma,  Umashanker Navik, Kulbhushan Tikoo , The Journal of Nutritional Biochemistry, ISSN: 0955-286, (2020), 84, 108442, DOI: 10.1016/j.jnutbio.2020.108442 (IMPACT FACTOR:6.117).
  15. Dietary Supplementation of Methyl Donor l‐Methionine Alters Epigenetic Modification in Type 2 Diabetes, Umashanker Navik, Vaibha G Sheth,  Shaheen Wasil Kabeer, Kulbhushan Tikoo, Molecular nutrition  food research, ISSN: 1613-4133, (2019), 63, 1801401, DOI: 10.1002/mnfr.201801401 (IMPACT FACTOR:6.575)
  16. Nanocrystalline solid dispersions (NSD) of hesperetin (HRN) for prevention of 7, 12-dimethylbenz[a]anthracene (DMBA)-induced breast cancer in Sprague-Dawley (SD) rats, Sneha Sheokhand, Umashanker Navik,  Arvind Kumar Bansal, European Journal of Pharmaceutical Sciences, ISSN:0928-0987, (2019), 12, 240-249, DOI: 10.1016/j.ejps.2018.12.006 (IMPACT FACTOR:5.112).
  17. Effect of diethyldithiocarbamate in cyclophosphamide-induced nephrotoxicity: Immunohistochemical study of superoxide dismutase 1 in rat, Vaibhav G Sheth,  Umashanker Navik, Krishna Prahlad Maremanda, Gopabandhu Jena, Indian Journal of Pharmacology, ISSN: 0253-7613,  (2018), 50, 4, DOI: 10.4103/ijp.IJP_850_16 (IMPACT FACTOR:1.2).
  18. Umashanker Navik, Sheth VG, Tikoo K. Assessing the effects of dietary L-Methionine supplementation induced epigenetic alterations in type 2 diabetes.  International Journal of Applied Sciences Research and Review. (10.21767/2394-9988-C1-008).  (Conference Paper)

Book Chapter

  1. Chapter title: Evolution of Zebrafish as a Novel Pharmacological Model in Endocrine Research. Umashanker Navik, Pushkar Singh Rawat, Prince Allawadhi, Amit Khurana, Anil Kumar Banothu & Kala Kumar Bharani, Book Title: Zebrafish Model for Biomedical Research, https://doi.org/10.1007/978-981-16-5217-2_6
  1. Chapter Title: Microbiome in Pulmonary Tuberculosis. Arnab Rakshit, Aarti Verma, Saloni Verma, Gurjit Kaur Bhatti, Amit Khurana, Jasvinder Singh Bhatti, Snehal Sainath Jawalekar, Umashanker Navik. Book Title: Microbiome in Inflammatory Lung Diseases. Springer, Singapore, https://doi.org/10.1007/978-981-16-8957-4_11
  2. Chapter Title: Targeting Mitochondria as a Novel Disease-Modifying Therapeutic Strategy in Cancer. Gurjit Kaur Bhatti, Paras Pahwa, Anshika Gupta, Umashanker Navik, P Hemachandra Reddy, Jasvinder Singh Bhatti. Book Title: Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Publisher: Springer, Singapore, https://doi.org/10.1007/978-981-15-9411-3_21
  3. Chapter Title: Novel Pharmacological Approaches for Diabetic Complications, Anchal Arora, Umashanker Navik, Aiswarya Jaiswal, Prabhsharan Kaur, Puneet Kumar*. Book Title: Diabetes and Diabetic Complications: Current Status and Future Prospective, Publisher: Nova Science ISBN: 978-1-53619-177-6
  4. Chapter Title: Various cellular and molecular axis involved in the pathogenesis of asthma. Gurjit Kaur Bhatti, Amit Khurana, Debapriya Garabadu, Prashant Gupta, Snehal Jawalekar, Jasvinder Singh Bhatti, Umashanker Navik*. Book Title: Targeting Cellular Signalling Pathways in Lung Diseases, Publisher: Springer Nature, Singapore https://doi.org/10.1007/978-981-33-6827-9_3
  5. Chapter Title: Therapeutic strategies targeting signaling pathways in lung cancer. Gurjit Kaur Bhatti, Paras Pahwa, Anshika Gupta, Umashanker Navik, Jasvinder Singh Bhatti. Book Title: Targeting Cellular Signalling Pathways in Lung Diseases, Publisher: Springer Nature, Singapore, https://doi.org/10.1007/978-981-33-6827-9_9
  6. Chapter Title: Targeting Mitochondria as a Novel Disease Modifying Therapeutic Strategy in Cancer. Gurjit Kaur Bhatti, Paras Pahwa, Anshika Gupta, Umashanker Navik, P. Hemachandra Reddy, and Jasvinder Singh Bhatti. Book Title: Handbook of Oxidative Stress in Cancer: Mechanistic, Publisher: Springer Nature, Singapore,    https://doi.org/10.1007/978-981-15-4501-6_21-1
Research Guidance

Ph.D. Students

  1. Poonam Yadav: October 2021: (ICMR-SRF Fellowship)

M. Pharm Students (2021-2023)

  1. Sumeet Singh
  2. Sampat Tanwar
  3. Dhaneshwari Patel

M.Pharm Students (2020-2022)

  1. Arnab Rakshit
  2. Saloni Verma
  3. Aarti Verma

M.Pharm Students (2019-2021)

  1. Pushkar Rawat
  2. Aiswarya Jaiswal

 

    Conference/ Workshops/Seminars Attended
    University Level
    National
    • Presented a poster at conference Cardiovascular Research Convergence 2017 at THSTI, Faridabad 
    International
    • Oral presentation (as a speaker) at EuroSciCon “European Conference on Epigenetics” at Paris, France.
    Conference/ Workshops/Seminars Organised