Assistant Professor
Department of Biochemistry
School of Basic and Applied Sciences
|
Ph.D. Life Science |
CSIR-Institute of Microbial Technology, Chandigarh-Jawaharlal Nehru University, New Delhi |
2015 |
Yeast genetics and Molecular biology |
|
M.Sc. Biochemistry |
Devi Ahilya Vishwavidyalaya, Indore |
2009 |
Biochemistry |
|
B.Sc. Biology |
University of Allahabad, Allahabad |
2007 |
Botany, Chemistry Biochemistry |
Ph.D. Vacancy
02 Ph.D. Positions are available in the lab. Interested Candidates with NET-JRF can contact us any time via email.
Research Experience
|
Assistant Professor |
Department of Biochemistry, School of Basic Sciences, Central University of Punjab, Bathinda. |
Jan 2020- Current |
|
Visiting Scientist |
Department of Plant Pathology and Weed Research, Agriculture Research Organization, Volcani Center, Israel. |
2017-19 |
|
Postdoctoral Fellow |
Department of Plant Pathology, The Hebrew University of Jerusalem, Israel. |
2016-17 |
Administrative Experience
Board of Studies (Member)
Curriculum design and development (Convenor)
AAC (Convenor)
Departmental Academic Integrity Panel (Member)
Any Other Experience
CRISPR/Cas9 mediated genome editing in plant and fungi
Sphingolipid biosynthesis and transport in fungi
Antifungal drug resistance in pathogenic yeast
Investigating oxysterol binding protein and lipids crosstalk in antifungal drug resistance of pathogenic fungi:
Oxysterol binding proteins are mainly involved in the transport of sterol and phosphatidylinositol 4-phosphate (PI4P) between membranes such as plasma membrane and endoplasmic reticulum, and these proteins are highly conserved from yeast to humans. Ergosterol, the main constituents of the yeast plasma membrane, influence sterol targeting drug action, such as azoles and polyenes. Amphotericin B (AmB), a polyene drug commonly used to treat fungal infection caused by pathogenic fungi Candida albicans and Cryptococcus neoformans. Recent studies have demonstrated that sphingolipid biosynthesis defective mutants also play a critical role in AmB drug resistance modulation but the exact mechanism involved is still unclear. Pathogenic fungi have been described as a global health threat due to their ability to cause invasive infections with a high mortality rate. The emergence of antifungal drug resistance in pathogenic fungi, prompt us for novel drug discoveries which are required urgently for combating pathogenicity caused by these pathogenic fungi. We are using molecular and cell biology approaches to explore the biochemical pathways involved in lipid exchanges and drug resistance.
- Investigating the impact of farnesol on sphingolipid biosynthetic pathway modulating membrane targeting antifungal drug resistance in Candida -Central University of Punjab, Bathinda, India (2020-2022). (Completed)
- Investigation on oxysterol binding protein and lipids crosstalk in antifungal drug resistance of pathogenic fungi -DST-SERB, India (2020-2022). (Completed)
- CRISPR/Cas9 mediated mutagenesis of lipid degradation pathway to generate highly efficient triacylglycerol producing Komagataella phaffii-UGC, New Delhi, India (2022-2024) (Ongoing)
- Investigation on sphingolipid and azole cross-talk in multidrug resistance Candida auris- ICMR, New Delhi, India (2022-2025) (Ongoing)
Indo-Israel Postdoctoral Fellowship 2017
Dr. Anil Thakur, Regional Centre for Biotechnology, Faridabad
Dr. Ritu Pasrija, Maharshi Dayanand University, Rohtak
| 21 |
S Kalra, S Tanwar, Vinay Kumar Bari. Overexpression of PDR16 Confers Amphotericin B Resistance in a PMP3-Dependent Manner in Yeast Saccharomyces cerevisiae. Microbial Drug Resistance.Vol. 30, No.7. https://doi.org/10.1089/mdr.2024.000 Corresponding author |
| 20 |
L Ahmady, M Gothwal, MM Mukkoli, Vinay Kumar Bari. Antifungal drug resistance in Candida: a special emphasis on amphotericin B. APMIS 132 (5), 291-316. https://doi.org/10.1111/apm.13389. Corresponding author |
| 19 |
Z Firdous, S Kalra, R Chattopadhyay, Vinay Kumar Bari. Current insight into the role of mRNA decay pathways in fungal pathogenesis. Microbiological Research, 127671, Corresponding author |
| 18 |
Sapna Kalra, Sunita Tanwar and Vinay Kumar Bari. Insights into the role of sphingolipids in antifungal drug resistance. Fungal Biology Reviews, Volume 47, March 2024, 100342. https://doi.org/10.1016/j.fbr.2023.100342. Corresponding author |
| 17 |
Puneet Jangir, Sapna Kalra, Sunita Tanwar and Vinay Kumar Bari. Azole resistance in Candida auris: mechanisms and combinatorial therapy. APMIS, Volume131, Issue 8, August 2023, Pages 442-462 ISSN:1600-0463, https://doi.org/10.1111/apm.13336. Corresponding author |
| 16 |
Kashish Madaan and Vinay Kumar Bari. Emerging Role of Sphingolipids in Amphotericin B Drug Resistance. Microbial Drug Resistance VOLUME 29, ISSUE 8 / AUGUST 2023. ISSN: 1076-6294. https://doi.org/10.1089/mdr.2022.0353. Corresponding author |
|
15 |
Vinay Kumar Bari, Dharmendra Singh, Jackline Abu Nassar, Radi Aly. Silencing of a mannitol transport gene in Phelipanche aegyptiaca by the tobacco rattle virus system reduces the parasite germination on the host root. Plant Signaling & behavior 2022. doi.org/10.1080/15592324.2022.2139115.*Corresponding Author |
| 14 |
Venkatramanan Mahendrarajan and Vinay Kumar Bari. A critical role of farnesol in the modulation of Amphotericin B and Aureobasidin A antifungal drug susceptibility. Mycology 2022, VOL. 13, NO. 4, 305-317. doi.org/10.1080/21501203.2022.2138599.*Corresponding Author |
| 13 | Radi Aly, Maor Matzrafi and Vinay Kumar Bari. Using biotechnological approaches to develop crop resistance to root parasitic weeds. Planta 253, 97 (2021). https://doi.org/10.1007/s00425-021-03616-1. |
|
12 |
Vinay Kumar Bari*, Jackline Abu Nassar, Ayala Meir and Radi Aly. Targeted mutagenesis of two homologous ATP-binding cassette subfamily G (ABCG) genes in tomato confers resistance to parasitic weed Phelipanche aegyptiaca. J Plant Res (2021). doi.org/10.1007/s10265-021-01275-7 *Corresponding Author |
|
11 |
Vinay Kumar Bari*, Jackline Abu Nassar and Radi Aly. CRISPR/Cas9 mediated mutagenesis of MORE AXILLARY GROWTH 1 in tomato confers resistance to root parasitic weed Phelipanche aegyptiaca. Scientific Reports 11, 3905 (2021). doi.org/10.1038/s41598-021-82897-8. *Corresponding Author |
|
10 |
Lilach Iasur Kruh, Vinay Kumar Bari, Jackline Abu-Nassar, Ofir Lidor and Radi Aly*. Characterization of an endophytic bacterium (Pseudomonas aeruginosa), originating from tomato (Solanum lycopersicum L.), and its ability to inhabit the parasitic weed Phelipanche aegyptiaca. Plant signaling and Behavior Volume 15 Issue 7. doi.org/10.1080/15592324.2020.1766292 |
|
9 |
Radi Aly, Vinay K. Bari, Avishai Londner, Jackline Abu Nassar, Leena Taha- Salaime, Hanan Eizenberg, Ran Lati. Development of specific molecular markers to distinguish and quantify broomrape species in a soil sample. European Journal of Plant Pathology. doi.org/10.1007/s10658-019-01841-9 |
|
8 |
Vinay Kumar Bari, Jackline Abu Nassar, Sally Merzouk Kheredin, Amit Gal-On, Mily Ron, Anne Britt, Daniel Steele, John Yoder and Radi Aly. CRISPR/Cas9-mediated mutagenesis of CAROTENOID CLEAVAGE DIOXYGENASE 8 in tomato provides resistance against the parasitic weed Phelipanche aegyptiaca. Scientific Reports 9, 11438 (2019). doi.org/10.1038/s41598-019-47893-z |
|
7 |
Manish Pareek, Yael Almog, Vinay Kumar Bari, Einat Hazkani-Covo, Itay Onn and Shay Covo. Alternative, functional, rad21 paralogs in Fusarium oxysporum. Frontier in Microbiololgy. 10:1370. doi: 10.3389/fmicb.2019.01370 |
|
6 |
R. Aly, R. Lati, J. Abu-Nassar, H. Ziadna, G. Achdari, C.S. von Muenchow, S. Wicke Vinay K. Bari and H. Eizenberg. The weedy parasite Phelipanche aegyptiaca attacks Brassica rapa var. rapa L. for the first time in Israel. Plant Disease Notes.doi.org/10.1094/PDIS-02-19-0285-PDN |
|
5 |
Radi Aly, Ran Lati, Vinay K. Bari, Jackline Abu-Nassar & Hanan Eizenberg. Use of a visible reporter marker- myb-related gene in crop plants to minimize herbicide usage against weeds. Plant Signaling and Behavior Volume 14, 2019 - Issue 4. doi.org/10.1080/15592324.2019.1581558 |
|
4 |
Dror Sagi, Evgeniya Marcos-Hadad, Vinay K. Bari, Michael A. Resnick and Shay Covo. 2017. Increased LOH due to defective sister chromatid cohesion is due primarily to chromosomal aneuploidy and not recombination. G3 Volume 7 | October 2017 | 3305.doi: 10.1534/g3.117.300091 |
|
3 |
Alfatah M, Vinay K. Bari Nahar AS, Bijlani S and K. Ganesan. 2016. Critical role for CaFEN1 andCaFEN12 of Candida albicans in cell wall integrity and biofilm Formation. 2017. Scientific Reports,volume 7, Article number: 40281 (2017), doi:10.1038/srep40281 |
|
2 |
Vinay K. Bari, Sharma, S., M. Alfatah, Alok K. Mondal and K. Ganesan. 2015. Plasma Membrane Proteolipid 3 Protein Modulates Amphotericin B Resistance through Sphingolipid Biosynthetic Pathway. Scientific Reports, volume 5, Article number: 9685 (2015). doi: 10.1038/srep09685 |
|
1 |
Sharma, S., M. Alfatah,Vinay K. Bari, Y. Rawal, S. Paul, and K. Ganesan. 2014. Sphingolipid Biosynthetic Pathway Genes FEN1 and SUR4 Modulate Amphotericin B Resistance. Antimicrobial Agents and Chemotherapy, April 2014, Volume 58 Number 4 p. 2409–2414.doi: 10.1128/AAC.02130-13 |
1. PhD Student -Sunita Tanwar (UGC-JRF)
2. PhD Student -Sapna Kalra (CSIR-JRF)
University Level
National
International
University Level
National Level
International Level
2. Online National workshop on “Curriculum design and Development” organized by School of Education, Central University of Punjab, Bathinda from July 21 - July 31, 2020.